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#rapamycin

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Caramelized Shallots<p>Peeps with long Covid who live in and around NYC </p><p>Mount Sinai is taking applications for a long covid clinical trial using low-dose rapamycin.</p><p><a href="https://ohai.social/tags/LongCovid" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>LongCovid</span></a> <span class="h-card" translate="no"><a href="https://a.gup.pe/u/longcovid" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@<span>longcovid</span></a></span> <a href="https://ohai.social/tags/rapamycin" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>rapamycin</span></a> <a href="https://ohai.social/tags/Sirolimus" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Sirolimus</span></a> <a href="https://ohai.social/tags/NYC" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>NYC</span></a> <a href="https://ohai.social/tags/NY" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>NY</span></a> <a href="https://ohai.social/tags/NJ" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>NJ</span></a> <a href="https://ohai.social/tags/CT" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>CT</span></a></p>
Norbert_R 🧣🐘🦣<p><a href="https://mastodon.social/tags/DoktorWhatson" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>DoktorWhatson</span></a></p><p>Wie dieser Mann versucht, den <a href="https://mastodon.social/tags/Tod" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Tod</span></a> zu umgehen</p><p>Softwaremillionär Bryan Johnson will das <a href="https://mastodon.social/tags/Altern" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Altern</span></a> besiegen. Sein Ansatz beinhaltet eine rigorose Überwachung seiner Gesundheit und eine Kombination aus Ernährung, Bewegung, Schlafmanagement sowie experimentellen Therapien wie <a href="https://mastodon.social/tags/Rapamycin" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Rapamycin</span></a>, Licht-Therapie und sogar <a href="https://mastodon.social/tags/Plasmatherapie" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Plasmatherapie</span></a>.</p><p><a href="https://www.yewtu.be/watch?v=53XfY1ATIWE" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="">yewtu.be/watch?v=53XfY1ATIWE</span><span class="invisible"></span></a></p>
Chuck Darwin<p>How a cheap, generic drug became a darling of longevity enthusiasts </p><p><a href="https://c.im/tags/rapamycin" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>rapamycin</span></a> has gained a large following thanks to longevity researchers and celebrity doctors who, citing <a href="https://c.im/tags/animal" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>animal</span></a> <a href="https://c.im/tags/studies" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>studies</span></a>, contend that rapamycin could be a game changer in the quest to fend off age-related diseases. </p><p>The drug is going mainstream as an anti-aging treatment, even though rapamycin’s 🔹regulatory approval is for treating transplant patients. 🔹</p><p>♦️There is no evidence that it can extend human life.♦️</p><p>Researchers have found that rapamycin can modify a kind of cellular communications system that gives cells certain directions <br>— to grow when the body has plenty of food and to slow down when nutrients are scarce. </p><p>The drug can dial down the signal to grow, causing cells to clear out accumulated junk and allowing them to run more efficiently.
<br>Despite the buzz surrounding the drug, it is unlikely that the Food and Drug Administration will ever approve it for longevity. </p><p>🔸The agency doesn’t consider aging to be a disease, 🔸and rapamycin’s generic status means 👉there’s little financial incentive to run expensive clinical trials to test it on age-related afflictions.</p><p><a href="https://www.washingtonpost.com/business/2024/03/15/rapamycin-longevity-drug/" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">washingtonpost.com/business/20</span><span class="invisible">24/03/15/rapamycin-longevity-drug/</span></a></p>
Rhyothemis<p>review article from 2015:</p><p>mTOR, a new potential target for chronic pain and opioid-induced tolerance and hyperalgesia</p><p><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4455918/" rel="nofollow noopener noreferrer" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">ncbi.nlm.nih.gov/pmc/articles/</span><span class="invisible">PMC4455918/</span></a></p><p><a href="https://doi.org/10.1186%2Fs12990-015-0030-5" rel="nofollow noopener noreferrer" target="_blank"><span class="invisible">https://</span><span class="ellipsis">doi.org/10.1186%2Fs12990-015-0</span><span class="invisible">030-5</span></a></p><p><a href="https://zeroes.ca/tags/ChronicPain" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ChronicPain</span></a> <a href="https://zeroes.ca/tags/Pain" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Pain</span></a> <a href="https://zeroes.ca/tags/mTOR" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>mTOR</span></a> <a href="https://zeroes.ca/tags/opioids" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>opioids</span></a> <a href="https://zeroes.ca/tags/rapamycin" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>rapamycin</span></a></p>
Andrew Steele<p>All the <a href="https://mas.to/tags/rapamycin" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>rapamycin</span></a> trials in the news this month! This is looking at using it in ME/CFS: <a href="https://meassociation.org.uk/2023/11/rapamycin-pilot-treatment-trial-for-me-cfs/" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">meassociation.org.uk/2023/11/r</span><span class="invisible">apamycin-pilot-treatment-trial-for-me-cfs/</span></a></p><p>The idea is that ME/CFS may be partly driven by dysfunctional autophagy (a process by which cells recycle waste), and rapa could help. Fascinating, I hope it works!</p><p><a href="https://mas.to/tags/aging" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>aging</span></a> <a href="https://mas.to/tags/agingbiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>agingbiology</span></a> <a href="https://mas.to/tags/me" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>me</span></a> <a href="https://mas.to/tags/cfs" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>cfs</span></a> <a href="https://mas.to/tags/mecfs" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>mecfs</span></a></p>
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