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#bioinformatics

15 posts14 participants2 posts today

A few images from yesterdays first #HoloDeck presentation at Prof. Varshneys #lab at the #Indian Institute of #Science (#IISc) in #Bangalore (#India), where people enjoyed 'playing molecules'.

Holodeck, also known as the Rechenkraft.net #Molecular #AR Environment is our #OpenSource approach - based on the @tiltfive hardware - to visualize molecular #structures in #3D for #education & #research & #development purposes.

Cloud computing: where you're not just a bioinformatician, you’re also the finance manager, compliance officer, and IT support, all while carrying a hefty dose of mental fatigue. I miss those PhD days with a inhouse HPC when all you had to do was sbatch every parameter combo under the sun to test your research question… then complain about queue times and who was clogging the damn cluster with their BLAST jobs 😅
#bioinformatics

#Genetic data repo #OpenSNP to self-destruct before authoritarians weaponize it
The reason, according to #bioinformatics researcher Bastian Greshake Tzovaras, one of the founders of the project, is the dissolution of genetic testing biz #23andMe and the potential weaponization of genetic data by #farright #authoritarian regimes.
theregister.com/2025/04/01/ope

The Register · Genetic data repo OpenSNP to self-destruct before authoritarians weaponize itBy Thomas Claburn

#Genomics
#Bioinformatics
#Academia

Beware US academic coders. If you have collaborators contributing code from a sanctioned region, your repos may be locked.

See mastodon.social/@organicmaps/1

The kicker is that the US is leaning authoritarian and all in on censorship. If Canada or Mexico become sanction targets and you have code pushes from there, Microsoft will lock you out of your GitHub accounts.

GitHub read-only
MastodonOrganic Maps (@organicmaps@mastodon.social)Attached: 1 image We have a temporary glitch with GitHub—probably some contributor was geolocated in a sanctioned region (no details yet). All required documents to unlock the account have been uploaded. Don't blame Microsoft/GitHub - it is just U.S. law. Please be patient. It should be unblocked soon.

Does anyone have any posts or past toots they could reshare about how they have setup or are working within a team in #bioinformatics, #genomics, #research etc. things that how worked or haven’t worked, organising and sharing projects and code, notes and documentation, collaboration and communication, software, network and local or cloud compute arrangement. Always find reading others experiences insightful and beneficial.

As I face the prospect of analyzing a dataset with 3 variables: time (3 time points), temperature (2), exposure to chemical (2); but only 2 biological replicates, please, people, consult a biostatistician before doing your experiments.

Please, please, please, talk to someone in data analysis *before* running these kinds of experiments. If there isn't enough money for *more samples*, drop one of the factors so there are more "N" for the remaining ones.

Continued thread

3/8 🧬📊 For the first time (or do update us), we've modelled dynamic, plant gene circuits with absolute units for both RNA and protein copies per cell.

You can compare our mathematical models directly to your biochemical data. Over time, both approaches should benefit! #SystemsBiology

4/8 🤖🧪 Those absolute units mean that we can predict the DNA-binding dissociation constants (Kd) of our clock transcription factors in vivo, for example.

After some tricky calibration, we estimated comparable Kd values in vitro from our earlier data and the literature, extending the method to any promoter sequence (more on this later).

So, did they match?